Depending on the different histopathological patterns, cell types and clinical features different variants of papillary carcinoma thyroid have been described. Prevention and treatment information (HHS). Papillary carcinoma thyroid (PTC) is the most common differentiated malignancy of thyroid gland. Follicular thyroid cancer accounts for about 10-15% of all thyroid cancers. Thyroid papillary carcinoma of columnar cell type is considered an uncommon histologic subtype of papillary carcinoma characterized by its morphologic features and purportedly aggressive biologic course. Sen A, Nalwa A, Mathur SR, Jain D, Iyer VK. 2018 Sep-Oct;19(5):1000-1005. doi: 10.3348/kjr.2018.19.5.1000. However, the histologic picture was dominated by cells with a clear to vacuolated-appearing cytoplasm similar to that seen in association with secretory-type endometrium. Columnar cell variant of papillary thyroid carcinoma (PTC) is an uncommon variant with an aggressive course as compared to classic papillary carcinoma. Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid, accounting for approximately 80% of all cancers at this … CCV-PTC was reported in 1986 by Evans for the first time. Popular - most common malignant neoplasm of the thyroid. 3. Indeed, the 2015 American Thyroid Association (ATA) Initial Risk Stratification System recommended to classify patients with aggressive variants of papillary thyroid carcinoma (e.g., tall-cell, hobnail variant, columnar-cell carcinoma) at ATA intermediate risk of disease recurrence and/or persistence. Pre-Tx iodine scan. columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is a rare subtype, which accounts for 0.15−0.2% of all PTCs (4). The histologic features The clear cell variant of papillary thyroid carcinoma (ccPTC) is even more infrequent—making conclusions regarding prognosis difficult. Due to its rarity, currently there is a lack of knowledge about this variant; especially the clinical importance, management approach and prognosis. The patient died 7 months after diagnosis. This study aimed to investigate the CCPTC prognosis using the Surveillance, … The publication of the article of Enriquez et al 1 coincided with the final steps of our study on the expression of CDX2 in normal and neoplastic follicular-derived cells of the human thyroid gland. We report a case of a 29-year-old white woman who presented with a large thyroid mass extending into the mediastinum with local and distant metastases. A total thyroidectomy was subsequently performed, and the final pathology report indicated a columnar cell variant of papillary thyroid carcinoma without extrathyroidal spread. Objectives: Thyroid cancers are frequently diagnosed and treated by otolaryngologists. Cytologic diagnosis of these tumors is difficult due to absence of characteristic nuclear features of classic pattern of papillary carcinoma. Columnar cell variant of papillary carcinoma (CCV-PC) thyroid is a rare and aggressive tumor composed of tall columnar cells that form papillae, glands and solid structures. 1998 May;18(5):352-6. doi: 10.1002/(sici)1097-0339(199805)18:5<352::aid-dc10>3.0.co;2-h. Adv Anat Pathol. Thyroid papillary carcinoma of columnar cell type: a clinicopathologic study of 16 cases. Primary mucoepidermoid carcinoma (MEC) of the thyroid and columnar cell variant of papillary carcinoma of the thyroid (PCT) are uncommon neoplasms. Background: Columnar cell papillary thyroid carcinoma (CCPTC) is a rare variant of papillary thyroid carcinoma (PTC), whose prognosis, as defined by the American Thyroid Association (ATA) guidelines, is considered poor, although available evidence is insufficient for reliable assessment. It is different from the typical papillary carcinoma, not only in morphology but also in biological behavior, and is more aggressive than typical papillary carcinoma. Post-S Copyright © 2021 Elsevier B.V. or its licensors or contributors. Copyright © 2004 American Academy of Otolaryngology–Head and Neck Surgery Foundation, Inc. The most common etiologic factor is radiation, but genetic susceptibility and other factors also contribute to the development of papillary thyroid carcinoma. This tumor followed an aggressive course with widespread metastatic disease unresponsive to all therapeutic intervention. This site needs JavaScript to work properly. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma (SCC) of the thyroid occurs is still a controversial issue. BACKGROUND: Columnar cell variant is a recognized rare variant of papillary thyroid carcinoma (PTC) that has an uncertain clinical course. Columnar Cell Variant (CCV) Clinical presentation: These tumors are rare. Aggressive Variants of Papillary Thyroid Carcinoma: Hobnail, Tall Cell, Columnar, and Solid. Papillary thyroid carcinomas are the most common thyroid cancers and constitute more than 70% of thyroid malignancies. It is more common in women with an M:F ratio of 1:2.5 (range 1:1.6-3:1) 2. Cytojournal. Virchows Arch. 2. Please enable it to take advantage of the complete set of features! Introduction. Korean J Radiol. Subsequently, it has been emphasized in several reports that the carcinoma was highly aggressive usually resulting in fatality , , , , , , .But recently, there are some reports of cases of encapsulated columnar-cell carcinoma … Epub 2018 Aug 6. Other variants of papillary thyroid cancer (columnar, diffuse sclerosing, and tall cell) are not as common and tend to grow and spread more quickly. The columnar cell variant of thyroid papillary carcinoma is an aggressive tumor associated with widespread dissemination and a fatal outcome. https://doi.org/10.1016/j.otohns.2004.06.682. 2011 Nov-Dec;31(6):644-7. doi: 10.4103/0256-4947.87104. Results: A 53-year-old female was referred to our clinic for a left anterior neck mass consistent with a thyroid goiter. Enriquez et al 1 evaluated CDX2 expression in 11 cases of columnar cell variant (CCV) of papillary thyroid carcinoma (PTC) and in thyroid tissue microarrays … In addition, areas of solid growth and organoid or glandular features were also identified. Columnar-cell carcinoma of the thyroid gland was first described by Evans in 1986 as an aggressive variant of thyroid carcinoma. 5. Papillary thyroid cancer (as is the case with follicular thyroid cancer) typically occurs in the middle-aged, with a peak incidence in the 3rd and 4th decades. Published by Mosby, Inc. All rights reserved. 2020 Jul;37(7):3112-3128. doi: 10.1007/s12325-020-01391-1. Tall cell variant of papillary thyroid carcinoma with foci of columnar cell component. Unable to load your collection due to an error, Unable to load your delegates due to an error. The patient’s postoperative course was uncomplicated, and she has shown no evidence of recurrence or metastasis. Papillary thyroid carcinoma (PTC) variant characterized by presence of ≥ 30% of tall cells (2 - 3 times taller than wide) with abundant granular eosinophilic (oncocytic-like) cytoplasm and the typical nuclear changes of PTC Variable diagnostic criteria over time with significant interobserver variability (Thyroid 2017;27:1498) Microscopic features : Accessibility Pérez F, Llobet M, Garijo G, Barceló C, Castro P, Bernadó L. Diagn Cytopathol. Emad R, Maha A, Kfoury HK, Al-Sheikh AM, Zaidi SN. Otolaryngologists should be familiar with this condition and the associated controversy in its prognosis. Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review. We present an additional case recently diagnosed and treated at our institution. The histologic features included focal papillary growth with columnar cells and nuclear stratification. Clinicopathological and molecular characterization of nine cases of columnar cell variant of papillary thyroid carcinoma. Bethesda, MD 20894, Copyright Columnar cell carcinoma of the thyroid gland: a case report and review of the literature. The columnar cell variant of thyroid papillary carcinoma is an aggressive tumor associated with widespread dissemination and a fatal outcome. Columnar cell variant of papillary thyroid carcinoma (PTC) is an uncommon variant with an aggressive course as compared to classic papillary carcinoma. [FIGURE 2 OMITTED] The columnar cell variant of PTC was first reported by Evans in 1986. 1. This means that if you have it, you’ll likely not experience any symptoms. Columnar Cell … Palpable lymph nodes. Single reports describe distant metastases of ccPTCs as well as co-occurrence with anaplastic thyroid carcinoma (ATC). Otolaryngologists should be familiar with this condition and the associated controversy in its prognosis. To the Editor. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Thyroid squamous cell carcinoma is very rare. The most common variants include conventional, follicular variant and tall cell variant. Epub 2020 Jun 1. A review of the literature revealed this to be a rare disease, accounting for fewer than 30 cases reported since its identification in 1986. We use cookies to help provide and enhance our service and tailor content and ads. The tumor was encapsulated and showed no evidence of extrathyroidal spread. A fine needle aspirate resulted in an indeterminate finding consistent with a possible follicular neoplasm. Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A. Adv Ther. National Library of Medicine The most common form, papillary thyroid carcinoma, has been divided into various histologic subtypes, one of which is the columnar cell variant. Clear cell variant of papillary thyroid carcinoma is considered a very rare morphologic variant. Columnar cell papillary thyroid carcinoma prognosis: findings from the SEER database using propensity score matching analysis. Background: Columnar cell variant is a recognized rare variant of papillary thyroid carcinoma (PTC) that has an uncertain clinical course. The incidence of clear cell papillary thyroid cancer is estimated to be around 0.5%. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Columnar cell variant of papillary thyroid carcinoma. The columnar variant of papillary thyroid carcinoma can be aggressive, particularly in older patients, with larger tumors showing a diffusely infiltrative growth pattern and extrathyroidal extension. Fine-needle aspiration cytology of columnar-cell carcinoma of the thyroid: report of two cases with cytohistologic correlation. Wang S, Xiong Y, Zhao Q, Song H, Yi P, Liu C. Am J Transl Res. Hashimoto’s thyroiditis (HT) is considered to be an independent risk factor for thyroid cancer, under the basis of HT, how … Columnar cell variant of papillary thyroid carcinoma is the rare subtype of PTC, which is reportedly about 0.17%. Columnar Cell Variant Thyroid Gland Papillary Carcinoma (Concept Id: C1333120) A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells. Would you like email updates of new search results? The revised American Thyroid Association guidelines recently categorized the PTC variants according to their biological behavior as described in the literature, and CCV-PTC was classified as the aggressive type (5). This is only the second reported case of columnar cell carcinoma to occur in a female.
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