Am J Clin Pathol 2002;117:16-8. Papillary thyroid cancer generally grows very slowly, but can often spread to lymph nodes in the neck. METHODS. The majority of papillary thyroid carcinoma (PTC) cases comprise classic papillary (C-PTC) and follicular variant (FV-PTC) histologic sub-types. A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. Rivera M, Ricarte-Filho J, Knauf J, et al. 2002 Jan;117(1):16-8. Thompson LD. Objective To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. Endocr Pract 17:765–787. BACKGROUND: The encapsulated follicular variant (EFV) of papillary thyroid carcinoma (PTC) is the most discussed entity in thyroid pathology. Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary carcinoma of thyroid. FVPTC has lower mortality and less frequent distant metastases than FTC, but higher mortality and more frequent distant metastases than cPTC. eFVPTCs appear to have a lower rate of cervical lymph node metastases compared with neFVPTCs, but recurrent disease may be seen in both subtypes. Encapsulated forms of the follicular variant with the absence of certain adverse features has led to another variant termed noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP), which is currently considered to not be a cancer. 8600 Rockville Pike It also can spread elsewhere in the body. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. The former is useful in identifying the follicular variant of papillary thyroid carcinomas. Khan A, Baker SP, Patwardhan NA, Pullman JM. Ganly I, Wang L, Tuttle RM, Katabi N, Ceballos GA, Harach HR, Ghossein R. Hum Pathol. Encapsulated follicular variant of papillary thyroid carcinoma is a common thyroid gland cancer, with a highly indolent behavior. Papillary Thyroid Cancer. Khan A, Baker SP, Patwardhan NA, Pullman JM. Some PTCs with classical papillae can be totally or partially encapsulated, and these tumors are called “encapsulated” (conventional) variant of papillary thyroid carcinoma. Encapsulated follicular variant papillary carcinoma with invasion of tumor capsule and/or vessels, 7.1%. 3. Copyright © 2017 Elsevier Inc. All rights reserved. Am J Clin Pathol. Virchows Arch 1998;432:427-32. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Surgical … Bethesda, MD 20894, Copyright Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant. Unable to load your collection due to an error, Unable to load your delegates due to an error. Of the 68 patients, 59 (87%) had eFVPTC and 9 (13%) had neFVPTC. The encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) demonstrates highly indolent behavior. Pathol Int. World J Surg. A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid. Request PDF | On Nov 1, 2002, Jennifer L Hunt and others published Encapsulated follicular variant of papillary thyroid carcinoma | Find, read and cite all the research you need on ResearchGate 2. Methods: … Fifty-four of 64 patients (84%) who had a total thyroidectomy received radioactive iodine. Tall-cell carcinoma: Tall-cell carcinoma is a more aggressive form of thyroid carcinoma that differs from the usual form by showing tall columnar cells. Mod Pathol. Follicular-patterned lesions of the thyroid: the bane of the pathologist. Papillary carcinoma of thyroid: classical and variants. 2002 Jan;117(1):143-50. doi: 10.1309/8VL9-ECXY-NVMX-2RQF. Papillary thyroid cancer is the most common type of thyroid cancer. However, serious issues remain regarding the reproducibility of the diagnosis, its position in the scheme of thyroid neoplasms, and the clinical implications of the diagnosis. Strict morphologic criteria should be applied to its microscopic … Encapsulated papillary thyroid carcinoma, follicular variant: a misnomer. There is no comprehensive, community hospital based longitudinal evaluation of encapsulated follicular variant of papillary thyroid carcinoma. Mod Pathol. Epub 2020 Aug 25. 2002 Oct;118(4):602-3; author reply 605-6. We aimed to investigate the clinicopathological features of this variant, comparing with non-encapsulated conventional type PTC. In addition, we review the literature on the relationship between SCM and different thyroid lesions, … Objective . Careers. Seethala RR, Baloch ZW, Barletta JA, Khanafshar E, Mete O, Sadow PM, LiVolsi VA, Nikiforov YE, Tallini G, Thompson LD. 2018 Jan;31(1):39-55. doi: 10.1038/modpathol.2017.130. Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and. Papillary thyroid cancer gets its name from the papillae among its cells, visible on microscopy.Features include: Characteristic Orphan Annie eye nuclear inclusions (nuclei with uniform staining, which appear empty due to powdery chromatin and marginal micronucleoli) and psammoma bodies on light microscopy. Verhulst P, Devos P, Aubert S, Buob D, Cranshaw I, Do Cao C, Pattou F, Carnaille B, Wemeau JL, Leteurtre E. Virchows Arch. Kim MJ, Won JK, Jung KC, Kim JH, Cho SW, Park DJ, Park YJ. 2018 Jul;42(7):2277-2278. doi: 10.1007/s00268-017-4351-6. KL2 TR000428/TR/NCATS NIH HHS/United States. Endocrine. Mod Pathol. Infiltrative follicular variant papillary carcinoma without a complete tumor capsule, 1.7%. 2011 Feb;35(2):313; author reply 314. doi: 10.1097/PAS.0b013e318206eebb. Epub 2017 Oct 20. Clipboard, Search History, and several other advanced features are temporarily unavailable. Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update. 2018 Jun;65(6):e26966. 2002 Jan;117(1):16-8. doi: 10.1309/P7QL-16KQ-QLF4-XW0M. Follicular variant of papillary thyroid carcinoma represents 30% of all papillary thyroid cancers and, like the classic type of papillary cancer, has a good prognosis overall. The review included specimens from 109 patients with noninvasive encapsulated follicular variant papillary thyroid carcinoma that was confined to a thyroid capsule and who were not treated with radioactive iodine and observed for 10 to 26 years. Virchows Arch 1998;432:427-32. 2016; 29 … Figure 1. Pediatr Blood Cancer. Encapsulated follicular variant is characterized by the presence of a complete capsule or well circumscribed border and usually RAS mutation. 2017 Jan;29(1):20-24. doi: 10.1097/CCO.0000000000000341. Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: A name change to Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features would help prevent overtreatment. Thyroid. Variants of Papillary Thyroid Carcinoma (Microcarcinoma, Tall Cell, Columnar, Follicular) Papillary thyroid microcarcinoma Tall Cell Variant (TCV) Columnar Cell Variant (CCV) Follicular Variant (FV) When a consensus decision is made, it will be reflected in the revised MP/H (to be known as Solid Tumor) rules. Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: A name change to Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features would help prevent overtreatment. Historically, clinical equivalency was assumed, but recent data suggest C-PTC may have poorer outcomes. Thyroid… One of these, known as the encapsulated follicular variant, 2 is particularly treacherous because its follicular architecture and well-differentiated nature results in a marked similarity with a follicular adenoma when it is encapsulated and with a hyperplastic nodule when it is not. Scharpf J, Kamani D, Sadow PM, Randolph GW. This site needs JavaScript to work properly. Only a handful of publications have described cases of SCM in the thyroid and we add to that literature by reporting a unique case of encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with SCM. Capsular and vascular invasion may be present; if no capsular or vascular invasion present, should have widespread nuclear features of papillary carcinoma PLUS some additional features of papillary carcinoma (papillae, fibrous bands, dense eosinophilic colloid), otherwise diagnose as follicular adenoma or well differentiated thyroid neoplasm of uncertain malignant potential Recently, reclassification as a non-malignant neoplasm has been proposed. To distinguish aggressive cancers from more benign lesions more clearly, the objective of this study was to determine if the eFVPTC behaves less aggressively than the nonencapsulated variant (neFVPTC). Retrospective studies have found that noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) exhibits highly indolent clinical behavior. Parente DN, Bongers PJ, Verzijl R, Rotstein LE, Asa SL, Kluijfhout WP, Devon KM, Goldstein DP, Mete O, Pasternak JD. 2018 Jul;42(7):2279. doi: 10.1007/s00268-018-4505-1. Mod Pathol. This site needs JavaScript to work properly. Mod Pathol. A proposal for the classification of follicular-patterned neoplasms of the thyroid gland. None of the patients had distant metastasis or died of their disease. CD 57 [leu-7] expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma. Epub 2016 Apr 22. The prognosis for patients with such tumors is better than the prognosis for patients with unencapsulated papillary carcinoma. The encapsulated follicular variant of papillary carcinoma has become one of the most common diagnoses in thyroid tumor pathology. Follicular variant papillary thyroid carcinoma (FVPTC) encompasses follicular variant, encapsulated with invasion (encompassing capsular invasion with and without vascular invasion) as well as follicular variant, infiltrative. Samples were rereviewed to determine if the tumor was eFVPTC or neFVPTC, which were correlated with patient outcomes. Encapsulated follicular variant of papillary thyroid cancer: are these tumors really benign? 2018 Mar;28(3):311-318. doi: 10.1089/thy.2016.0671. The purpose of this study is to document the incidence and further assess the clinical outcomes of reclassifying … World J Surg. Objective: To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. Would you like email updates of new search results? The mean age was 48 y and 63% were female. The follicular variant of papillary thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The patient did not develop lymph node or distant metastasis and did not develop recurrent disease after 19 years of follow‐up. Mod Pathol. Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? 15. Clipboard, Search History, and several other advanced features are temporarily unavailable. A review of follicular variant papillary thyroid carcinoma and a proposal for a new classification. 840 - 844 Article Download PDF CrossRef View Record in Scopus Google Scholar Gambardella C, Tartaglia E, Nunziata A, Izzo G, Siciliano G, Cavallo F, Mauriello C, Napolitano S, Thomas G, Testa D, Rossetti G, Sanguinetti A, Avenia N, Conzo G. World J Surg Oncol. Bethesda, MD 20894, Copyright It accounts for about 80% of all thyroid cancers. 2012 Mar;62(3):155-60. doi: 10.1111/j.1440-1827.2011.02773.x. Mod Pathol. For now, you can report noninvasive follicular thyroid neoplasm with papillary-like nuclear features as a synonym for encapsulated follicular variant of papillary thyroid carcinoma and assign 8340/3. Excluding “carcinoma” from the new terminology shifted NIFTP out of the malignant category and altered Bethesda System for Reporting Thyroid Cytopathology (BSRTC) rates of malignancy … Background: Recent studies suggest that the encapsulated form of follicular variant of papillary thyroid cancer (eFVPTC) behaves more similarly to benign lesions and can be treated with thyroid lobectomy alone instead of total thyroidectomy. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. We studied the clinical features of our patients with noninvasive EFVPTC tumors culled from a community endocrine surgical practice registry over the past four years. Methods. Accessibility 2019 Jun;64(3):433-440. doi: 10.1007/s12020-019-01887-z. Am J Surg Pathol. Chan JK. Hernandez-Prera JC, Valderrabano P, Creed JH, de la Iglesia JV, Slebos RJC, Centeno BA, Tarasova V, Hallanger-Johnson J, Veloski C, Otto KJ, Wenig BM, Yoder SJ, Lam CA, Park DS, Anderson AR, Raghunand N, Berglund A, Caudell J, Gerke TA, Chung CH. Gross and Histopathologic Features of the Tumor Currently Known as Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (EFVPTC) A, Gross appearance of a tumor with thin capsule. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. Thyroid. Encapsulated follicular variant of papillary thyroid carcinoma is a common thyroid gland cancer, with a highly indolent behavior. Conclusions: Am J Clin Pathol. Epub 2015 Feb 4. Encapsulated follicular variant of papillary thyroid carcinoma. Follicular variant of papillary thyroid carcinoma is a unique clinical entity: a population-based study of 10,740 cases. The objective of this study was to assess the behavior of FVPTC, espe-cially its encapsulated form, and shed more light on its true position in the clas-sification scheme of well differentiated thyroid carcinoma. 2010;23(9):1191-1200.Google Scholar Crossref Would you like email updates of new search results? Why there is the tendency to "overdiagnose" the follicular variant of papillary thyroid carcinoma. 2016 Sep 19;14(1):247. doi: 10.1186/s12957-016-1003-5. 2013 Oct;23(10):1256-62. doi: 10.1089/thy.2013.0018. Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: a name change to noninvasive follicular thyroid neoplasm with papillary-like nuclear features would help prevent overtreatment. Ethics Approval and Informed Consent This study was approved by Medical Ethics Committee of Chinese PLA General Hospital (S2019-178-02) and the requirement for informed consent was waived because the patients’ data were evaluated retrospectively and anonymously. Earlier, they have been regarded as variants of papillary thyroid carcinoma (PTC), hyperplastic lesions, and follicular neoplasms. Recent studies suggest that the encapsulated form of follicular variant of papillary thyroid cancer (eFVPTC) behaves more similarly to benign lesions and can be treated with thyroid lobectomy alone instead of total thyroidectomy. N2 - IMPORTANCE Although growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer. Eightee …. Encapsulated papillary oncocytic neoplasms (EPONs) of the thyroid are rare tumors, whose relationship to other thyroid tumors has not been thoroughly elucidated. J Clin Pathol. 2002 Oct;118(4):603-5; author reply 605-6. Results: In the second patient with an 0.8cm isthmic noninvasive ... with suspected noninvasive encapsulated follicular variant of papillary cancers. Prevention and treatment information (HHS), National Library of Medicine Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) was classified as a malignant tumor in the 3rd edition WHO classification of thyroid tumors. Papillary thyroid carcinoma, Follicular Variant, 2.1 cm in greatest dimension, present in mid to lowe pole, woth prior FNA site changes. Laryngoscope 120:712–716. Am J Clin Pathol. Document this in a text field. Epub 2019 Mar 13. Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary carcinoma of thyroid.
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