There are limited data on the role of neck ultrasound (US) in the surveillance of patients with follicular thyroid cancer (FTC). Thyroid. Considerable controversy exits when discussing the management of well differentiated thyroid carcinomas (papillary and even We searched thirteen databases from January 2006 to December 2020 to find all relevant, full-text journal articles written in English. MATERIALS AND METHODS. The result of ultrasound examination demonstrating thyroid lesion, which turned out to be follicular cancer on histopathological examination. Analyses assessed the accuracy of malignancy detection in case of follicular lesions, potentially differentiating FTA and FTC included the odds ratio (OR), sensitivity, specificity, positive and negative predictive values. 8 – 10 However, Hagag et al 11 reported that sonographic findings did not have a predictive role for carcinoma in follicular tumors. of thyroid gland like thyroid follicular cells, calcitonin- producing C cells, lymphocytes, stromal and vascular ele-ments. Thyroid nodules have diverse presentations. 2018 Oct;37(10):2325-2331. doi: 10.1002/jum.14580. J Ultrasound Med. Here, we analyze the likelihood of US to find structural disease in patients with FTC and evaluate if initial American Thyroid Association (ATA) risk stratification and the response to therapy categories [the latter based on thyroglobulin (Tg) levels] modify that … High-resolution US is a first-step imaging technique used to evaluate the morphologic characteristics of thyroid nodules. Breast cancer screening. doi: 10.1007/s12022-018-9560-5. eCollection 2020. The aim of our study was to perform a meta-analysis to identify sonographic features suggesting malignancy in the case of follicular lesions, potentially differentiating FTA and FTC. 2014;124(3):97-104. doi: 10.20452/pamw.2132. an x-ray test that produces detailed cross-sectional images of your body from the bottom of your brain to the middle of Thyroid. Methodological flow diagram of the meta-analysis for sonographic features differentiating follicular thyroid cancer…, The graphic presentation of overall specificity, sensitivity, negative prognostic value (NPV), and positive…, The result of ultrasound examination demonstrating thyroid lesion, which turned out to be…, National Library of Medicine Based on Tg levels, 24/32 patients had excellent response to therapy and 8/32 had biochemical incomplete/indeterminate response. 2004 Dec;29(4):161-74. We conducted a retrospective cohort study of 32 patients with FTC in our institution. Follow-up of low risk thyroid cancer patients: can we stop follow-up after 5 years of complete remission? Accessibility Follicular thyroid cancer is characterized by the following US features: Iso- to hyper-echoic Thick irregular halo Compared to follicular carcinoma, follicular adenoma is benign and occurs more commonly with a ratio estimated to be 5 to 1. Thyroid cancer occurs in the cells of the thyroid — a butterfly-shaped gland located at the base of your neck, just below your Adam's apple. After thyroid cancer surgery, patients are divided into low, intermediate and high risk groups. There is no recommended screening test to find thyroid cancer early for people at average risk. A slow forming disease, papillary thyroid cancer typically strikes between the ages of 30 and 50, and affects women more than men. Compared to follicular carcinoma, follicular adenoma is benign and occurs more commonly with a ratio estimated to be 5 to 1. lesions are typically hypoechoic usually lacks cystic change 2 ; Nuclear medicine. Privacy, Help Pathol. doi: 10.1089/thy.2017.0500. Blood tests or thyroid ultrasound can often find changes in the thyroid, but these tests are not recommended as screening tests for thyroid cancer unless a person is at increased risk, such as having a family history of thyroid cancer. Certain ultrasound features are associated with an increased risk of thyroid malignancy. -, Borowczyk M., Szczepanek-Parulska E., Olejarz M., Wieckowska B., Verburg F.A., Debicki S., Budny B., Janicka-Jedynska M., Ziemnicka K., Ruchala M. Evaluation of 167 Gene Expression Classifier (GEC) and ThyroSeq v2 Diagnostic Accuracy in the Preoperative Assessment of Indeterminate Thyroid Nodules: Bivariate/HROC Meta-analysis. Peiling Yang S, Bach AM, Tuttle RM, Fish SA. 2015;373:2347–2356. Accessibility Here, we analyze the likelihood of US to find structural disease in patients with FTC and evaluate if initial American Thyroid Association (ATA) risk stratification and the response to therapy categories [the latter based on thyroglobulin (Tg) levels] modify that likelihood. Zhao L, Zhu XY, Jiang R, Xu M, Wang N, Chen GG, Liu ZM. J Clin Endocrinol Metab. Dynamic Risk Estimates of Outcome in Chinese Patients with Well-Differentiated Thyroid Cancer After Total Thyroidectomy and Radioactive Iodine Remnant Ablation. * 3 patients in the US negative group had indeterminate US that was proven negative on follow up. Suspicious ultrasound findings can be further evaluated using fine-needle aspiration, with the needle washout fluid also tested for thyroglobulin. Specific US features, such as hypoechogenicity, taller‐than‐wide shape on transverse view, irregular margins, microcalcifications, and extrathyroidal extension, are recognized to be associated with cancer. Frequent screening with serial neck ultrasound is more likely to identify false-positive abnormalities than clinically significant disease in the surveillance of intermediate risk papillary thyroid cancer patients without suspicious findings on follow-up ultrasound evaluation. doi: 10.5603/EP.2018.0014. 1 However, many … The most common thyroid cancer, PC, usually produces a solid hypoechoic nodule with a well or poorly defined margin, and up to 80% display small foci of punctate calcification [6] (Fig. Twenty studies describing sonographic features of 10,215 nodules met the inclusion criteria. Treatment tends to revolve around local surgical treatment and radioactive iodine. 2015 Sep 1;8(9):11236-47. eCollection 2015. Low risk versus high risk, p = 0.14, Fisher’s exact test. Bethesda, MD 20894, Copyright Certain ultrasound features are associated with an increased risk of thyroid malignancy. Role of GPER1, EGFR and CXCR1 in differentiating between malignant follicular thyroid carcinoma and benign follicular thyroid adenoma. Relation between response to therapy categories based on Tg response (excellent or incomplete/indeterminate) and finding structural disease on ultrasound (n=32). Follow-up of differentiated thyroid carcinoma. *…, Relation between response to therapy categories based on Tg response (excellent or incomplete/indeterminate)…, National Library of Medicine Follicular thyroid cancer typically concentrates pertechnetate, but not radioiodine. Shen FC, Hsieh CJ, Huang IC, Chang YH, Wang PW. Sonographic features of medullary thyroid carcinomas--a systematic review and meta-analysis. -. The authors declare no conflict of interest. FINDINGS: Postsurgical changes of total thyroidectomy, central compartment lymph node dissection and right modified radical neck … Endokrynol Pol. The tumour may be described as a thyroid nodule on ultrasound imaging. Endokrynol. Int J Clin Exp Pathol. Prevention and treatment information (HHS). A random-effects model was used to summarize collected data. There are several issues of current importance for determining whether a thyroid nodule is a thyroid cancer. -, Munoz Perez N., Villar del Moral J.M., Muros Fuentes M.A., Lopez de la Torre M., Arcelus Martinez J.I., Becerra Massare P., Esteva Martinez D., Canadas Garre M., Coll Del Rey E., Bueno Larano P., et al. 2014;65(4):314-8. doi: 10.5603/EP.2014.0043. Słowińska-Klencka D, Wojtaszek-Nowicka M, Sporny S, Woźniak-Oseła E, Popowicz B, Klencki M. BMC Endocr Disord. Would you like email updates of new search results? We extracted a total of 60 radiomics features derived from the first order, shape, gray-level … Please enable it to take advantage of the complete set of features! None of the patients with excellent response had structural disease by US versus 2/8 (25%) patients with biochemical incomplete/indeterminate response all of whom had other sites of structural disease (p = 0.054). Introduction. 2015 Apr;100(4):1561-7. doi: 10.1210/jc.2014-3651. 2008 Aug;27(8):1179-84. doi: 10.7863/jum.2008.27.8.1179. Papillary Thyroid Carcinoma Recurrence: Low Yield of Neck Ultrasound With an Undetectable Serum Thyroglobulin Level. -, Cibas E.S., Ali S.Z. 2019;30:8–15. -, Jarzab B., Dedecjus M., Slowinska-Klencka D., Lewinski A., Adamczewski Z., Anielski R., Baglaj M., Baldys-Waligorska A., Barczynski M., Bednarczuk T., et al. Thyroglobulin (Tg) can be used as a tumor marker for well-differentiated follicular thyroid cancer. Keywords: Epub 2014 Jan 28. Treatment and prognosis. Eur J Endocrinol. Cancer rehabilitation. The predictive value of sonographic images of follicular lesions - a comparison with nodules unequivocal in FNA - single centre prospective study. 2020 May;182(5):D1-D16. Follicular thyroid cancer; Structural disease; Ultrasound. Differentiation of thyroid nodules with macrocalcifications: role of suspicious sonographic findings. doi: 10.1007/s00423-013-1070-9. Privacy, Help J. Med. Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50 years of age. follicular lesion of unknown significance; follicular neoplasm; follicular thyroid cancer; thyroid; ultrasonography. INTRODUCTION. Non-invasive follicular thyroid neoplasm with papillarylike nuclear features (NIFTP) is a new name for a very low risk thyroid tumor previously known as an Encapsulated Non-invasive Follicular Variant Papillary Thyroid Carcinoma. Pol. We included all patients with well-differentiated FTC who underwent total thyroidectomy and radioactive iodine (RAI) treatment without neck structural disease at the time of RAI and with Tg and US at least 6 months after RAI. 2020 Apr 22;11:235. doi: 10.3389/fendo.2020.00235. FOIA However, they were studied mainly in papillary thyroid cancers (PTCs); these results cannot be simply extrapolated for the differentiation of follicular thyroid adenomas and cancers (FTAs and FTCs). Your thyroid produces hormones that regulate your We aimed to evaluate whether radiomics analysis based on gray-scale ultrasound (US) can predict distant metastasis of follicular thyroid cancer (FTC). However, they were studied mainly in papillary thyroid cancers (PTCs); these results cannot be simply extrapolated for the differentiation of follicular thyroid adenomas and cancers … Tg excellent response versus Tg incomplete/indeterminate, p = 0.057, Fisher’s exact test. Careers. N. Engl. See this image and copyright information in PMC. You are at greater risk of developing this disease if you have a personal or family history of goiters, have been exposed to high levels of radiation in the past, or certain genetic endocrine diseases. Epub 2017 Jan 23. The most crucial feature associated with an increased risk of FTC is capsule protrusion, followed by the presence of calcifications, irrespectively of their type. J Ultrasound Med. The highest overall ORs to increase the risk of malignancy were calculated for tumor protrusion (OR = 10.19; 95% confidence interval: 2.62-39.71), microcalcifications or mixed type of calcifications (coexisting micro and macrocalcifications): 6.09 (3.22-11.50), irregular margins: 5.11 (2.90-8.99), marked hypoechogenicity: 4.59 (3.23-6.54), and irregular shape: 3.6 (1.19-10.92). The primary tumor typically appears as a highly infiltrative mass about the thyroid gland. P01 CA124570/CA/NCI NIH HHS/United States, P50 CA168505/CA/NCI NIH HHS/United States, NCI CPTC Antibody Characterization Program. Several retrospective studies have described the sonographic appearance of thyroid follicular neoplasms and suggested that a hypoechoic mass on sonography, as well as male sex, a nodule size larger than 40 mm, and a solitary mass, indicates an increased risk of thyroid follicular carcinoma. This article will focus more on the follicular type of thyroid cancer, discussing the etiology, epidemiology, histology, evaluation, staging, and complications of follicular thyroid cancer. 8600 Rockville Pike The 2017 Bethesda System for Reporting Thyroid Cytopathology. Most of the time, patients in the low risk group are simply monitored by ultrasound. Patients in the intermediate and high risk groups are usually selected to be treated with radioactive iodine. This site needs JavaScript to work properly. Epub 2018 Mar 2. Could 18F-FDG-PET/CT avoid unnecessary thyroidectomies in patients with cytological diagnosis of follicular neoplasm?
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